Technology & Know-How

Naturamole uses biocatalytic processes and natural substrates as an alternative to traditional chemical synthesis and petrochemistry.

Known as ''white biotechnology'', industrial biotechnology uses enzymes or micro-organisms as

natural micro-factories for the industrial manufacture of specific molecules.

We are also experts in "green biotechnology", which allow us to combine both domain and provide our customers with products

that are linked to the phyto-world and processed with biotech means.

Enzymatic Catalysis

Naturamole uses biocatalytic processes and natural substrates as an alternative to traditional chemical synthesis and petrochemicals to make natural and sustainable molecules.

Also known as "white biotechnology", industrial biotechnology uses enzymes or micro-organisms as natural micro-factories for the industrial manufacture of molecules.

Naturamole's distinct approach combines the best of genomics, microbiology, chemistry and process engineering, bringing great value, competitiveness and environmental performance to the market.

We serve this market by providing innovative products and tailor-made bioprocesses, challenging multiple industrial applications in food, feed, fragrances, cosmetics and fine chemicals worldwide.

Microbial Fermentation

Fermentation processes use living micro-organisms, i.e. bacteria, yeast and fungi, to produce high-value molecules from nutrient substrates (biosynthesis) or specific precursors (bioconversion).

Considered as microfactories, these microbial cells can be wild type or genetically modified to achieve higher productivity and profitability.

Naturamole has a long and rich history in the various fermentation technologies from 1L to 2m3, and our experience in enzymatic catalysis has given us extensive knowledge in this field.

As for enzyme catalysis, our integrative approach aims at optimising both the microorganisms - through natural biodiversity screening for wild type microorganisms and synthetic biology for recombinant microorganisms - the fermentation environment - composition of the medium, temperature, pH, feed rate... - and the bioreactor, specifically designed for high productivity.

Examples of applications

Production of natural 6-Pentyl-Alpha-Pyrone by a wild-type filamentous fungus

Production of Cis-3-Hexenol by recombinant yeast

Baeyer-villigerases used for the transformation of linear ketones into esters or cyclic ketones into lactones

Ene-reductases used to reduce C=C bonds

Alcohol dehydrogenases used to convert aldehydes into alcohols

W3-desaturase to generate unsaturated fatty acids from saturated fatty acids